گزارش يك مورد تجويز ريتوكسيماب در يزد در بيماري استيل با شروع در بزرگسالي

Rituximab in Adult -Onset Stillʹs Disease: Case Report

Summary: Adult-onset Stillʹs disease (AOSO) is a rare systemic inflammatory disorder of unknown etiology. It is characterized by high grade fever, skin rash, arthritis, leukocytosis, increased ESR, CRP and liver enzyme levels and high levels of ferritin. The treatment of AOSO includes NSAIDs, steroids, and disease-modifying antirheumatic drugs (DMARDs). Recently biologic agents have been used for treatment of some rheumatologic disorders. Ritux imab(MabThera), an anti-C020 monoclonal antibody is one of the biologic agents which is used by only a few researchers for treatment of refractory AOSD. Herein, we describe a 23 year old woman, who was treated with Rituximab ,three years after diagnosi s of AOSO .She did not respond to Metotroxate and Cellcept .After administration of Rituximab, clinical and laboratory remission was achieved.