بررسي ارزش تشخيص همزمان ديلاتاسيون سرويكس و اينترلوكين هاي 6 و 8 در مايع سرويكوواژينال جهت پيش گويي زايمان زودرس

Studying the Combination of Cervical Interleukins -6 and -8 with Cervical Dilatation in Predicting Preterm Labor

Some biochemical markers such as FFN (fetal fibronectin), ILIB (interleukin IB), IL6, and ILg in cervical mucus have been used to predict pretenn delivery. The aim of this study was to assess the combination of two factors (cervical dilatation (1-2cm) with IL6 and ~ levels) to predict pretenn delivery. This was a prospective follow-up study. The study population consists of normal singleton pregnant women between 24-34 weeks of gestation. Patients divided in two groups: first group had 1-2 em cervical dilatation and second group had no cervical dilatation . Cervical fluid was sampled from uterus external os and analyzed for IL6 and ILg with ELIZA in both of groups . Pretenn delivery and levels of IL6 and ILg were asses sed. The relation between IL6 and ILs levels and cervical dilatation with pretenn delivery was determined , Sensitivity, specificity, positive predictive value and negative predictive value of IL6 and ILg and their relation with dilatation and pretenn delivery were assessed. Data analyzed by SPSS-13 software and t-test, IL6 levels have more sensitivity and specificity for pretenn delivery. Sensitivity and specificity of cervical dilatation (1-2 ern) and IL6 > 1.8 pg/ml for predicting pretenn delivery were 50% and 65%, respectively. PPV and NPV were 28.6% and 82.4%, respectively. According to review articles, these two variables have not been used for pretenn delivery prediction. Low cervical dilatation (1-2cm) had significant relationship with pretenn delivery. Combination of cervical dilatation and IL6 can be used for predicting the pretenn delivery.