ميزان سرمي هورمونهاي تستوسترون - دهيدرواپي آندروسترون سولفات (DHEA-S ) پرولاكتين، هورمون لوتئيني (LH) و هورمون محركه....

Evaluation of serum level of testosterone , Dehydropiandrosterone sulphate (DHEA-S) prolactin, Luteinizing Hormone (LH) Follicle stimulating hormone (FSH) in women with hirsutism.

Introduction: Hirsutism is a common problem in young women that may be, sign of internal glands diseases (eg: ovary, adrenal, hypophysis,...) The aim of this research was measurment of serum level of hormones that produce by these glands in women with hirsutism. Materials and Methods: In this cross-sectional, descriptive research, in all the hirsute women that referred to Dermatology clinic of Jahrom from April 2004 to April 2005 serum level of Testosterone, Dehydroepiandrosterone-sulphate (DHEA-S), prolactin, Luteinizing hormone (LH) and Follicle-Stimulating Hormone (FSH) was measured with ELISA method. Testosterone > 1.2 ng/ml. DHEA-S > 41 fig/ml, prolactin > 25 ng/ml and LH/FSH>3 was considered abnormal. Data was analysed by chi-square method. Results: Out of 81 patients who was referreds , 59 patients (72.8%) had positive FHx of hirsutism and 42 pts (52%) had irregular mensturation. Serum testosterone, DHEA-S and prolactin was high in 9.9%(7pts of 71pts), 12.7% (lOpts of 79pts) , 10.1% (8pts of 79pts) respectively and 23.8% (19pts of 80 pts) had LH/FSH>3. High level of serum testosterone. DHEA-S and prolactin didnʹt have significant correlation with irregular mensturation (P=.429, .087, .713 respectively), Positive FHx (P= .67, .452, 1.000 respectively) and marrital status (P=.684, .73, .707 respectively). LH/FSH>3 had significant correlation with irregular mensturation (P<0.001), But didnʹt have significant correlation with age (P=0.126), merrital status (p=.784) and positive FHx (P=.648). Overall 34 pts (42/5%) had at least one abnormality in their laboratory examination (testosteran or DHEA-St or prolactin or LH/FSH >3). Conclusion: Out of 81 pts, 59 pts (72.8%) had positives FHx of hirsutism so it seems that genetic has significant role for inducing of hirsutism. Many pts with hirsutism [34 pts (42.5%)] had at least one hormonal abnormality so as screening tests, measurment of hormones such as testosterone, DHEA-S, prolactin, LH and FSH is neccessary in pts with hirsutism.