عفونت با ويروس سايتومگال در بيماران كانديد پيوند كليه در بيمارستان الزهرا اصفهان

Cytomegalovirus Infection in Renal Recipients in AL-Zahra Hospital of Isfahan

Introduction: Patients with renal transplant who receiving immunosuppressive drugs are prone to any opportunistic infections such as CMV. This study is planed to detect the prevalence of anti CMV before transplantation and long term follow up of active CMV disease incidence. Materials and Methods: In this descriptive analytic study, all of the 70 patients who candidate for renal transplantation during 1381-1384 studied in Al-Zahra Hospital of Isfahan. After filling questionires, Elisa test for anti CMV (IgM, IgG) performed and prevalence of these antibodies calculated. Also prevalence of these antibodies calculated according to age and gender and six months follow up was done for incidence of acute CMV disease following transplantation. Results: 70 patients studied among them 64 (91/4%) had IgG-anti CMV (59/4% male and 40/6% female). 2 person had IgM-anti CMV that both of them were female (100%). There was relationship between anti CMV IgG prevalence and age (P<0/01) and no relationship of anti CMV IgG and gender. There was no any relationship of anti CMV IgM and age/gender, 2 cases (2/8%) of active CMV disease occurred after transplantation and one of them rejected the transplant. Conclusion: According to the prevalence of anti CMV IgG among studied patients there was high risk of reactivation which causing sever complication and transplant rejection so this recommendable to rapid diagnosis, prevent sever infection and mortality by performing CMV serology before transplant, detecting antigenemia PP (65) and PCR weekly as a screening test.