اجزاي سوم و چهارم سيستم كمپلمان در زنان با سابقه اتلاف حاملگي مكرر

C3 and C4 in Women with Recurrent Pregnancy Loss

Introduction: Fetal loss and recurrent abortion account for significant emotional distress for couples desiring children. Regarding the etiologic importance, this study has been carried out to determine the serum level of C3 and C4 in women with recurrent miscarriage. Material and Methods: This case control study was carried out in Shariatee hospital of Bandar Abbas University of Medical Sciences, during 2000-2001. 109 women with definite diagnosis of recurrent abortion or fetal loss as patients and 220 matched women with at least two successful deliveries and negative history of miscarriage as controls were studied. The sera of the patients and the controls were tested by SRID method for determining C3 and C4. Results: The prevalence of reduced serum levels of C3 and C4 in the patients and the controls were 22.02% and 5% respectively and that of C4 in the patients and the controls were 24.77% and 8.18%, respectively. There was a significant difference between the prevalence of reduced serum level of C3 and C4 in the patients and controls ( p<0.001). Conclusion: The results of this study suggest that the complement system plays a significant role in recurrent miscarriage. Further studies are needed to explore the role of immune system - classical pathway of complement system-in fetal loss and spontaneous abortion.