تاثير مكمل ياري روي بر ترميم شكستگي استخوان هاي دراز

Effect of Zinc Supplementation on Fracture Healing of Long bones

Background: Bones are one of the high-concentration resources for zinc (Zn). Animal studies have shown that zinc deficiency would result in disturbing the bone growth, bone volume and the force required for breaking oneʹs bones. The present study was conducted to investigate the effects of Zn supplementation on healing of fractured bones. Materials and Methods: This randomized, double-blinded, placebo controlled clinical trial was conducted on 60 patients with long-bone fractures referred to shohada hospital in the city of Tabriz. Subjects were randomly divided into 2 groups; case group (n=30): receiving one capsule of 220 mg/day zinc sulfate consist of 50 mg zinc each day each day, and control group (n=30): receiving placebo, subjects received supplement for 60 days, physical activity, individual and clinical information were gathered in a questionnaire. Nutritional intake was determined by a three-day food records both at the beginning and at the end of the trial. Condition of fracture was evaluated by radiographic studies at the beginning and the end of trial. Results: Out of 60 patients, 39 were male and 21 were female. There was no significant change in the physical activity, sex, age education, history of fracture, the fractured long bone and nutrient intake pattern (especially zinc intake) between two groups. The change in nutrient intake means was not significant. After 60 days, radiologic assessments showed a significant change (P<0.05) in callus formation and fracture healing in case group compare to those of control group. Callus formation and fracture healing in case group was 80% whereas in control group it was 50% . Conclusion: The study suggests that the supplement of zinc for 60 days, stimulates fracture healing in the long bones and since there have been no acceptable pharmacological agent for the therapy of bone fracture, zinc compound may play a unique role in this regard.