تفاوت جنسي د رحجم نيمكره هاي و بطنهاي جانبي مغز در مبتلايان به اسكيزوفرني به كمك تصويربرداري با رزونانس مغناطيسي MRI

Sexual Dimorphism in Volume of the Cerebral Hemispheres and Lateral Ventricles in Schizophrenia Using Magnetic Resonance Imaging.

Purpose: This study is designed to determine the sexual dimorphism pattern in volume of the cerebral hemispheres and lateral ventricles in schizophrenia using magnetic resonance imaging (MRI) and to compare it with normal sexual dimorphism pattern in healthy brains. Materials and Methods: This study is performed on 29 healthy volunteers (21 males, 8 females ) and 29 patients suffered from schizophrenia (21 males, 8 females) after exact psychiatric examinations based on DSM-IV criteria. Males and females in each group were in the same age. The brains of patients and controls serially sectioned in full coronal series of 1.5mm thickness by a 1.5 tesla MRI. The volumes of whole brain, hemispheres, and lateral ventricles and the ventricular - Brain Ratios (VBRS) were estimated by Cavalieriʹs principle. Finally the sex difference for each parameter was evaluated by t-student and non - parametrical Mann- Whitney tests. Results: The volumes of the whole brain and each of its hemispheres were significantly smaller in healthy females than those males (P<0.005). The volume of the right ventricle was also smaller in healthy females than those males (P<0.05). The volume of both lateral ventricles was tended to be smaller in females than males (0.05