ارزيابي پاسخ به درمان دارويي در بيماران مبتلا به آندوكارديت باكتريال براساس يافته هاي باليني و پاراكلينيكي

Evaluation of Response to Drug Treatment in Patients with Endocarditis Based on Clinical and Laboratory Findings

Background and Objects: Pervalance and conditions that cause infective endocarditis are increasing todays. Early recognition and treatment of endocarditis should be applied as a medical emergency. Purpose of this study is to obtain clinical and paraclinical criteria for response to treatment in patients with infective endocarditis. Materials and Methods: In a descriptive cross sectional study, 27 hospitalized patients with infective endocarditis based on the duke criteria have been studied .All patients received venous antibiotic treatment. During hospitalization, patients evaluated for responses of treatment on the base of clinical and paraclinical data and echocardiography. A questionnaire used for obtaining patientʹs information and the responses to treatment. Results: Of 27 patients 77.8% (p=0.00) had fever, 37% (p=0.125) had leucocytosis, where as 100% (p=0.003) showed positive CRP, Abnormal Echocardiography and systemic symptoms, which reached to normal ranges after treatment. Mean ESR at admission time was 90.67 (±14.62) mm/h and at end of treatment decreased to 80.81 (±17.21) mm/h. 29.6% (p= 0.00) of patients had positive RF at the end declined to 11.1% (p=0.00). Mean CIC was 171.74 (± 27.25) which reached to 98.19 (±34.96) (p=0.00), after treatment. 74% of patients showed abnormal U/A and at the end decreased to 7.4% (p=0.002). 100% patients had negative blood culture (p=0.008). Conclution: Variation of C-reactive protein, Circulating immune complexes, rheumatoid factor, urinalysis, and contitional symptoms at first and of along the treatment is helpful for evaluation of the treatment and detection of probable complication