اثر عصاره هيدروالكلي برگ گياه زيتون بر ميزان آنزيم هاي آسپارتات آمينوترانسفراز و آلانين آمينوترانسفراز سرم در موش هاي صحرايي مسموم شده توسط تتراكلريد كربن

Effect of olive leaves on serum AST and ALT levels in CCl4-induced liver damage in rats

Olive (Olea europeae L.) is a tree that has been used as a hepatoprotective and antioxidant agent in traditional medicine. In present study, the protective effects of ethanolic extract of olive leaves in rats were evaluated. Wistar rats were orally treated with olive leaves extract (10, 100, 200 and 400 mg/kg) along with administration of CC14 (50% CC14/sunflower oil; 1 ml/kg) for 28 days. The results showed that the treatment of olive leaves extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers AST (aspartate amino transferase) and ALT (alanine amino transferase). Therefore, the results of the study suggest that the extract could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be attributed to its modulation on detoxification enzymes, its antioxidant and free radical scavenger effects.