بررسي مقايسه اي اثرات تجويز سرپايي ايزوسوربايد منونيترات و دارونما جهت آماده سازي سرويكس قبل از تحريك زايمان

Randomized Double Blind Placebo Controlled Trial Of Outpatient Cervical Ripening with Isosorbide Mononitrate Prior To Induction Of Labor

Background: Our aim was to examine the efficacy and safety of isosorbide mononitrate (IMN) for cervical ripening and labor induction. Methods: Two hundred and forty pregnant women of at least 41 week gestation with a bishop score <5 were selected for a double blind trial, to randomly receive either 60 mg of vaginal IMN or a vaginal placebo. Findings: Fifty-four percent treated with IMN went to active phase of labor compared to thirty-one percent in the placebo group (p