سنجش اعتبار شاخص هاي افتراقي در غربالگري بتا- تالاسمي مينور

Evaluation of Discrimination Indices Validity for Screening of^-Thalassemia Trait

Background and Objectives; p-thalassemia trait (p-TT) and iron deficiency anemia (IDA) are the most common forms of microcytic anemia. Screening of P-thalassemia trait is important for medical counseling before marriage and preventing p-thalassemia major birth results. The most common problem in screening p-TT is differentiating it from IDA. The aim of this study was to define the sensitivity, specificity, and predictive values of some discrimination indices for screening of p-TT in a sample of such patients. Methods: A total of 82 patients with microcytic anemia (MCV< 80 fl) were selected from Namazi Hospital, Shiraz, Iran, and 9 discrimination indices were calculated for them. The patients were divided intotwo groups: 42 patients with P-TT and 40 patients with IDA. The sensitivity, specificity, positive and negative predictive values and Youdenʹs index of each discrimination index were calculated for screening p-TT. Results: None of the discrimination indices showed 100% of sensitivity and specificity. But the Shin and Lai index, RDW index and RBC count showed the highest and valuable value for screening p-TT. Conclusion: Some discrimination indices like Shin and Lai index, RDW index and RBC index are valuable indices in screening p-TT.