بررسي تاثير پليمرهاي HPMC K100M و كاربوپول 974P بر خصوصيات شناوري و رهش ايندومتاسين از سيستم هاي دارو رساني شناور

Effect of HPMC KlOOM and Carbopol 974P on Floating Characteristics and Release Profile of Indomethacin from floating Drug Delivery Systems

Objectives: Floating drug delivery system is one of the novel methods in drug delivery. This study evaluates the relationship and influence of formulation factors such as polymer type, drug: polymer ratio and gas forming agents on drug release and floating properties of matrices containing HPMC K100M and carbopol 974P and indomethacin as a model drug. Methods: In the present study attempt was made to form Indomethacin floating formulations using HPMC klOOM, carbopol 974P, lactose and floating agents in different ratios. Tablets were prepared by direct compression method. The physicochemical properties of tablets prepared were investigated. Rate of drug release was studied using USP II at pH 1.2 and 7.2. For study the release kinetics of indomethacin from the matrix tablets, the release data were fitted to the zero order, first order, higuchi and pepas equations. Results: The results showed that all the polymers used in this study could slow down the release of indomethacin from the matrices prepared. Addition of gas generating agent to the formulation containing HPMC alone can modify the floating properties of related matrices. Incorporation of carbopol was found to compromise the floating capacity of related formulations due to the difference in the basic properties of HPMC and Carbopol in water uptake potential. Conclusion: Results showed that the effect of combination of polymers and floating agents on drug release and its kinetic. The use of HPMC KlOOM and lactose in 1:1 ratio and incorporation of 5% of floating agents can lead to suitable floating formulation of indomethacin