ريزش پذيري، پرس پذيري? انحلال و سختي سيستم هاي liquisolid پيروكسيكام تهيه شده از ميكروكريستالين سلولز

Flowability, compressibility, dissolution and hardness of piroxicam liquisolid systems prepared by cellulose microcrystalline

Objectives: The technique of liquisolid compacts is a promising method to enhance the dissolution of poorly soluble drugs. Lower flowability and compressibility is one of the limitations of this technique. The evaluation of effects of the different grades of cellulose microcrystalline on flowability, compressibility and dissolution of liquisolid systems were the aim of this study. Methods: For this mean several formulations were prepared using various grades of cellulose microcrystalline as carrier. PG, silica and sodium starch glycolat were used as non-volatile solvent, coating material and disintegrant respectively. Then flowability, friability, hardness and dissolution rate of prepared formulation were studied. The effect of aging on mentioned properties was also investigated. Results: The results showed that among the evaluated different grades of cellulose microcrystalline, compacts contained cellulose microcrystalline PH 101 and 102 showed better dissolution profiles. Harder compacts were obtained using cellulose microcrystalline PH 101 and 200 as carriers. Better flowability observed in compacts containing cellulose microcrystalline PH 101. Also these compact demonstrated acceptable friability. Aging had no effect on hardness and dissolution profile of liquisolid tablets. Conclusion: It could be concluded that cellulose microcrystalline PH 101 is a suitable carrier for preparing of liquisolid systems for having acceptable flowability, friability, hardness and dissolution profile.