سميت خوراكي فنيتروتيون در رت ها: يك مطالعه اي بيوشيميايي و هيستوپاتولوژيك

Oral toxicity of fenitrothion in Wistar rats: a biochemical and histopathological study

The present study was undertaken to evaluate subacute tOXICIty of orally administered fenitrothion (FNT) in rats based on the biochemical and histological examination. The study was conducted on 8-week old male Wistar rats distributed into four groups (three experimental groups and one control group). They were treated orally with different doses (25, 50, 100 mg/kg BW) of fenitrothion for 28 consecutive days. After treatment, blood samples were collected for biochemical studies, also liver and kidney samples were taken for histological studies. Results indicated that the exposed groups led to significant dose-dependent increase in serum glucose and cholesterol levels. Total serum protein, albumin and triglycerides were decreased not significantly in the. exposed groups when compared with the control. The results also showed that the histopathological changes in·t~e liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leucocytic infiltration inʹthe portal area, severe congestion and hemorrhage. Marked tubular dilation, hydropic degenerescence in tubular epithelium, moderate congestion and hemorrhage in the cortical and medulla part of the kidney were recorded. Generally, the degrees of observed variations were found to be dose dependent