رابطه ميان غلظت Substance P و Calcitonin Gene Related Peptide با لثه نواحي مختلف دنداني

Relationship between SP and CGRP concentrations and different gingival regions

Background & Aim: It is not well established that why certain parts of gingiva are more susceptible to some kind of periodontal diseases, since these regions are adjacent to the foramen of some nerves and paths, and regarding to the important role of neuropeptides in inflammation. On the other hand, it was shown that SP and CGRP have some role in periodontal diseases, so the aim of this study was to determine the correlation between concentration of SP and CGRP and different regions of human clinically healthy gingiva. Methods & Materials. For this analytical study, 17 gingival samples from first maxillary incisor and first molar regions (case group) and 23 gingival samples from other regions (control group) were collected. Tissue samples were cultured for 72 hours. Then EIA was used for detection of SP and CGRP in supernatant fluids. Statistical analysis was made by Mann - whitney U test and Spearmanʹs correlation coefficient tests. Results: Both SP and CGRP were present in all samples. There was also significant difference between different gingival regions regarding to CGRP concentration so its concentration was lower in first molar regions (P-0.023). We could not find any significant difference between different regions regarding to SP concentration. Conclusion: It is suggested that SP and CGRP probably participate in the regulation and maintenance of gingival health and based on the lower concentration of CGRP in the gingiva of upper and lower first molars, it could be suggested a possible cause for susceptibility of these regions to some of oral diseases such as localized aggressive periodontitis.