بررسي مقاومت استافيلوكوكوس طلايي بيمارستاني به روش E-Test

Antibiotic Resistance of Nosocomial Staphylococcus Infections with E_Test Method

Background:Staphylococcus aureus is one of the most important etiologic agents causing severe infection in human. Extravagant use of vancomycin as first line treatment of infections caused by this organism, has led to production of vancomycin resistant staphylococci and enterococci, as an important health problem. The recommendations of international societies to control nosocomial infections , regarding making policies for vancomycin usage in health and treatment centers in order to prevent development and spread of vancomycin resistant Enterococcus and staphylococcus aureus. The goal of this study is determining sensitivity of S. aureus isolated from clinical specimens hospitalized patients using E-Test in order to find suitable primary therapeutic method. Methods:This study is Analytic descriptive, and 14 different antibiotics were evaluated using E-Test method at Al Zahra hospital in Isfahan . Quality control was implemented using staphylococcus ATCC 29213. Data were analyzed by SPSS -13 software and WHOnet-5 after editing and entering into computer. Findings:This study was done on 72 patients, 25 of whom were women and the rest were men. There was no meaningful relation between patients sex and the place of isolation of organisms , but regarding ward of hospitalization and resistance rate , highest resistance was observed in ICU and surgical wards (P<0.05) . Highest sensitivity is to vancomycin (93.5%) and then to Rifampin (87%) and amikacin (71.4%). Highest resistance is against doxycycline and oxacillin (75%) and then cotrimoxazole and ofloxacin with 69% resistance stand at next level. Conclusion-. Because of inadvertent use of antibiotics , specially in hospitals?ICU and surgical wards, the resistance of potentially dangerous and lethal bacteria like staphylococcus aureus is high and presently only a few drugs like vancomycin exist that can cover this bacterium