كليدواژه :
عصاره زيره كوهي , تمرين استقامتي , ليپوپروتيين هاي پلاسما , ليپيدها , موش سوري
چكيده لاتين :
Background and Objectives: The effect of endurance training on lipid profile and cardiovascular endurance in
normal rat after Bunium Persicum Extract (BPE) administration has been previously investigated. In the present
study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins
in hypercholesterolemic male mice was examined.
Material and Methods: In this experimental study, 60 male mice were, randomly, divided into 4 groups:
Vehicle, Endurance Training (ET), Bunium Persicum Extract Administer (BPEA) and ET-BPEA group. The
Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium
Persicum Extract was also administered in the same period and the desired dose (0.8 mg) was reconstituted in
0.4 ml of distilled water. The amount of Triglyceride (TG), Total Cholesterol (TC), HDL-c, LDL-c and Body
Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way
ANOVA method.
Results: The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous
extract administration reduced TC (pretest; 297.7±37.08, post test; 146.1±30.8, p=O.O 19) and LDL-c
concentrations (pretest; 151.8±14.4, post test; 0.12±8.7, p=O.OOI). On the other hand, Bunium Persicum aquous
extract administration increased HDL-c concentration significantly (pretest; 75.9± 12.1, post test; 119.9±17.9,
p=0.003). Furthermore, the results showed that body weight changes were not significant.
Conclusion: These results suggest that co-administration of BPE and ET could significantly affect plasma lipid
and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases.
