مقايسه ي اثر ضد دردي فلونيكسين مگلومين و كتوپروفن در درد حاصل از پراكسي نيتريت در خوكچه ي هندي

The Comparison Effects ofAnalgesics Flunixin Meglumine and Ketoprofen in Pain induced by Peroxynitrite in Guinea-Pigs

Background and objectives: Non steroidal anti inflammatory drugs (NSAIDs) are widely used to reduce inflammation, pain and fever. The present study was organized to induce an experimental inflammation in an animal model, using a putative biological oxidant, Peroxynitrite (ONOO-) and to study the effects of Flunixin meglumine and Ketoprofen on the pressure-induced pain. Materials and Methods: For this purpose, 24 male guinea pigs were divided into 4 groups each consisting of 6 animals. Three groups (groups 2, 3 and4) were injected Peroxynitrite and one group (the first: control) received physiological salt solution subcutaneously in the paw. After induction of a local inflammatory response, Flunixin meglumine (lmg/kg) and Ketoprofen (2 mg/kg) were injected to the second and third groups, 5 times with 12h intervals. The first and the fourth groups were injected saline solution in the same manner. Pressure analgesiometry was performed before and 1 hour \. after injections. Result: The animals in all 3 groups treated with Peroxynitrite demonstrated an increased sensitivity to painful pressure (P