بررسي ارتباط گيرنده هاي استروژن و پروژسترون با درجه داكتال كارسينوماي مهاجم پستان در زنان مراجعه كننده به مراكز پاتولوژي استان چهارمحال و بختياري

Correlations of estrogen or progesterone receptors with grade of invasive ductal carcinomas of the breast in women referred to pathology center in Chaharmahal va Bakhtiari province, Iran

Background and aim: Many factors are effective to prognostic breast cancer. One the most important of these factors is estrogen and progesterone receptors. The aim of this study was to detect frequency of invasive ductal carcinomas and to determine its correlation with grade of tumors. Methods: This descriptive analytical -study was performed on all women referred to the pathology center in Chaharmahal va Bakhtiari province (Iran) from 2001 to 2005. From the total patients, 56 people were diagnosed for invasive ductal carcinomas. Type and degree of tumor was diagnosed by Richardson Bloom system. Samples were stained for estrogen and progesterone receptors with immunohistochemistry method using Labeled Streptavidin Biotin (LSAB) technique. Data were analyzed using Chi square, t-test and ANOVA. Results: From the total patients, 56 cases were found with invasive ductal breast carcinoma. The mean age of patients was 49.45±13.4 years. The results from tumor gradation confirmed 22 patients with tumor type III, 20 patients with tumor type II and finally 14 patients with tumor type I. Estrogen and progesterone receptors were detected in 48.2% and 41.1% of the invasive ductal breast carcinoma, respectively. No significant relation was found between age and frequency of estrogen or progesterone receptors. The expression of estrogen and progesterone receptors was significantly associated with grading the carcinomas (P<0.001). Conclusion: Although enough frequency of estrogen and progesterone receptors was found in low grade invasive ductal breast carcinoma, but tissue differentiation in 75% of the patients was slight to moderate.