اثر مصرف كوتاه مدت زرشك سياه فرآوري شده بر روي عوامل خطر بيماريهاي قلبي-عروقي در بيماران ديابتي نوع II باسندرم متابوليك

Short Term-Effect of Processed Berberis Consumption Vulgaris on Cardiovascular Risk Factors in Type II Diabetes Patients with Metabolic Syndrome

Background and Objectives: Cardiovascular disease is the first outcome of metabolic syndrome. Therefore, management of cardiovascular disease risk factors is magnitude in patients with metabolic syndrome. This study was aimed to determine short term-effect of processed Berberis vulgaris consumption on cardiovascular risk factors in type II diabetes patients with metabolic syndrome. Materials and Methods: Type II diabetic patients were recruited into a clinical trial (n =57) and randomly assigned into three groups: 1) processed B. vulgaris (n =19), daily consumption of ITsp processed B.vulgaris in apple vinegar, 2) apple vinegar (n =19), daily consumption of 2Tsp apple vinegar and 3) control group with no change in their diet. Systolic and diastolic blood pressure, height and weight were measured at the baseline and end of week 4 and body mass index (BMI) was calculated. Blood samples were colleted after 12-14 h fasting at the baseline and end of week 4 and glucose, insulin, hs CRP and interleukin-6 concentrations were measured. Results: At the end of 4 weeks, nutritional intake of 3 groups did not differ from the baseline. However, mean of weight and BMI decreased significantly in processed B.vulgaris and apple vinegar. Systolic- and diastolic blood pressure and inflammatory markers (inc. hs CRP and interleukin-6, IL-6) concentrations did not change. Nevertheless, levels of glucose in processed B.vulgaris group, insulin in all groups and IL-6 in control group increased significantly. Conclusion: These findings indicate that processed B.vulgaris in apple vinegar had no effect on cardiovascular disease risk factors.