مقايسه سطح ليپوپروتيين هاي سرم در گلوگوم زاويه باز اوليه با هيپرتانسيون چشمي

A Comparison of the Serum Lipoprotein Level of Primary Open Angle Glaucoma with Ocular Hypertension

Background and Objectives: Ocular hypertension (OHT) is the most common cause of primary open- angle glaucoma (POAG). High serum lipoproteins level may be a potential risk factor for progressing of OHT to glaucoma. The aim of this study was to compare serum lipoproteins level in patients with POAG. Materials and Methods: In this case-control study intraocular pressure was measured with Goldman contact tonometer in 50 patients with POAG and 50 patients with OHT. Retinal examination and primary were performed in all individuals. In both groups with intraocular pressure greater than 21 mmHg with normal optic nerve and primary findings were considered as OHT and those with at least 2 abnormal findings from the 3 criteria considered as POAG. We allocated only those patients who were open angle in gonioscopy. In each group total cholesterol, LDL, HDL and triglycerides were measured. Results: Mean Serum triglyceride level POAG patients was 215.32 ± 44.28 mg/Dl and in OHT patients 195.02 ± 42.63 mg/dL. The difference between these two groups was statistically significant (P=0.022). Mean Serum Cholesterol average was 245.88 ± 34.40 mg/dL in POAG and 231.42 ±41.98 mg/dL in OHT patients. Conclusion: Serum Lipoproteins levels in POAG patients were more than OHT patients. Particularly hypercholesterolemia and hypertriglyceridemia may accelerate the progression of OHT to POAG.