مرکز منطقه ای اطلاع رساني علوم و فناوري - اثر ضدديابتي و وابسته به اندوتليوم مصرف خوراكي سير كوهي بر پاسخ انقباضي و رفع انقباضي آيورت سينه اي موش صحرايي ديابتي

چكيده لاتين :

Aims. Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of Allium schoenoprasum L. (AS). Thus, the endothelium-dependent effect of oral administration of AA for 8 weeks on contractile and relaxatory response of thoracic aorta from diabetic rats investigated. Materials & Methods. Male Wistar rats were divided into 5 "control", "AS-treated control", "diabetic", "AS-treated diabetic" and "glibenclamide-treated diabetic" groups. Treated groups received AS-mixed pelleted food at a weight ratio of 3%. Body weight and serum glucose level were measured before the study and at weeks 4 and 8. At the end of study, contractile reactivity of thoracic aortic rings to KC1 and phenylephrine and relaxatory response to acetylcholine and sodium nitroprusside were determined using isolated tissue setup. Results. Serum glucose level significantly decreased in AS-treated diabetic group versus untreated diabetics (p<0.05). In addition, endothelium-intact AS-treated diabetic group showed a significantly lower contraction to KC1 and phenylephrine (p<0.05) as compared to diabetic group and endothelium removal abolished this response. Meanwhile, relaxation response of endothelium-intact rings to acetylcholine was significantly higher in AS-treated diabetic group as compared to diabetics (p<0.05). In addition, there were no significant changes amongst the groups regarding relaxatory response to sodium nitroprusside. Conclusion. Chronic oral administration of AS through affecting endothelial-related agents can decrease contractile response and enhance relaxatory response in aortic tissue of diabetic rat and this may be beneficial in prevention of long-term vascular complications of diabetes.