كليدواژه :
آترواسكلروز , خرگوش , رگه چربي , شنبليله , كلوفيبرات , هيپرليپيدمي
چكيده لاتين :
Background: Atherosclerosis is the excess of fat and stiffness of arteries sidewalls in which specific areas of the circulatory system are involved, causing specific signs based on the involved area, the characteristics of the lesion, and the severity of involvement. The only factor necessary to cause atherosclerosis is the high level of LDL cholesterol. Today, drugs such as Lovastatin, Clofibrate, and Klystramyn are applied to reduce LDL and increase HDL levels. Materials and Methods: The effect of fenugreek seeds without any drugs or with Clofibrate on blood lipids profile and fatty streak forming were evaluated in 25 male healthy rabbits. The rabbits were divided into 5 groups of 5 and received the following diets and drugs for 45 days: Group I, normal diet without any drug; Group IT, high cholesterol diet without any drug; Group III, high cholesterol diet plus germinated fenugreek seeds powder (600 mg bid); Group IV, high cholesterol diet plus clofibrate (50 mg bid); and GroupV, high cholesterol diet plus clofibrate (50 mg bid) and germinated fenugreek seeds powder (600 mg bid).
The blood samples were collected after overnight fasting at the beginning and at the end of the test period and were estimated for lipids profile. Also autopsy and aortic cross-sectional sampling was conducted for microscopic study after the experiment.
Results: The serum total cholesterol, LDL, and triglyceride levels of groups III, IV,V increased less than those in group n but HDL levels in groups III, IV and V increased more than that in group n (P<0.001). Furthermore, the intensity of fatty streak was less in group V.
Conclusion: There results indicate the usefulness of fenugreek seeds in the management of hyperlipidemia and atherosclerosis (P<0.05)
