اثر تزريق داخل صفاقي و موضعي ويتامين B6 بر پاسخ درد ناشي از فرمالين در موش سوري

Effect of intraperitoneal and local injection of vitamin B6 on pain response induced by formalin in mice

The B-vitamin, pyridoxine (vitamin B6) importance in nutrition, axonal transport, excitability of neurons, or synthesis of neurotransmitters. A number of studies have shown that vitamin B6 has antinociception and antiinflammatory effects in a range of animal models (but not all animals). The aim of this study was to investigate the effect of intraperitoneal and local injection of vitamin B6 on formalin-induced pain and inflammatory in mice. In this experimental study, vitamin B6 (50mg/kg) was intraperitonealy injected 15 minutes and with 5% concentration (20Ml) was intrapawley injected 5 minutes before intrapawley formalin (20Ml, 5%) injection. The time of licking and biting of injected paw was measured as pain response at 5 minutes intervals for 1 hour. The results showed that formalin-induced a biphasic pain response (p<0.05) (first phase: 0-5 and second phase: 15-45 minute after injection). Intraperitonealy and local injection of vitamin B6 before formalin only reduced the second phase (inflammatory pain) of pain response significantly (p<0.05). Our results suggested that the vitamin B6 possess antinociceptive activity probably via a decrease on the release of neurotransmitters and other substances that promote nociception and inflammation. VetJ.of Islamic. Azad. Univ., Garmsar Branch. 4,2:59-67,2008.