بررسي اثر عصاره هيدرو الكلي ميوه گياه سرو كوهي (Juniperus communis) بر انحلال سنگهاي ادراري به سنگ هاي ادراري به صورت In vitro

In vitro effect ofjuniper fruit extract on dissolution of urinary stones

Background and purpose: Urolithiasis is one of the most common diseases of urinary tract. Abdominal colicky pain, nausia, vomiting and hematuria are the major clinical findings. Treatments including oral drugs, lithitripsy, using ureteroscope and open surgery are expensive and may result in significant complications. The aim of this research was to find medications for dissolution of urinary stones with less complication.Materials and methods: Variable concentrations of juniper fruit extract including 200, 500 and 1000 jig / ml solutions were used in vitro on urinary stones. Neutral (normal saline), positive (sodium bicarbonate) and negative (acetic acid) control groups were also prepared. Results: Significant findings were obtained on urinary stones composed of calcium oxalate (60%), calcium phosphate (30%) and ammonium phosphate (10%). The weight of dry powder of stones in normal saline of 1400 mg decreased to 1310 , 1240 and 1120 mg after exposure to increasing concentrations of juniper fruit extract. Also the ratio of calcium oxalate in normal saline aqueous solution plus stone increased from 65% to 85% after using juniper fruit extract. Conclusion: Juniper fruit extract can dissolve urinary stones in vitro.