شيوع آنتي بادي ضدهليكوباكتر پيلوري در افراد سالم و بيماران آرتريت روماتوييدي

Prevalence of Heliobacter pylori antibody in healthy people and patients with rheumatoid arthritis

Aim: Rheumatoid arthritis is a chronic disease which causes high costs. Evaluation and reduction of effective factors are useful in the incidence and severity of clinical manifestation of this disease. The aim of this study was to investigate the prevalence of Heliobacter pylori serology in patients with rheumatoid arthritis compared with healthy individuals.Methods: In this cross-sectional descriptive study, 159 persons who referred to rheumatology clinic of a hospital in Tehran were selected as participants of the study. The level of IgG, IgA and cytotoxin antibody depend on specific gene of Helicobacter pylori were evaluated in serum of individuals with ELISA test. Data were analyzed with independent sample T test and Levien test. Results: The average age of 91 patients with rheumatoid arthritis was 42.5+1.14 and 68 patients of control group were 39+1.4. Anti IgA and IgG serum level in rheumatoid arthritis group were 36.27+3.05 and 27.26+2.05U/ml respectively and their difference was statistically significant (p=0.016). But there was no significant correlation between the serum level of the IgG and cytotoxin antibody depend to specific gene of Helicobacter pylori in participants of patients and control groups (p>0.05). Conclusion: IgA serum level of Helicobacter pylori was higher in rheumatoid arthritis patients comparing with healthy people.