تاثير يك دوره فعاليت استقامتي بر سطوح ابستاتين پلاسما و معده موش هاي صحرايي نژاد ويستار

Effect of Endurance Training on Plasma and Stomach Obestatin Concentrations in Wistar Rat

Obestatin is a effective peptid on energy balance that identified in 2005. And there is no a lot of researches about this peptide. The purpose of this study was to investigate fundus obestatin concentrations responses to a treadmill exercise running program in Wistar rats. Fourteen Wistar male rats (12-14 weeks old, 235-250g) were divided into control and training groups. Training group was given exercise on a treadmill at 25 m/min for 60 min/day, 5 days/week for 6 weeks. Plasma, fundus and liver were excised for determination of obestatin and ATP concentrations and liver glycogen by ELISA process. Data analyses for determine of deffrence of mean between groups and in each group were done by using of indipended t-test and paired t-test. Obestatin concentrations were significantly low in trained rat fundus. Liver glycogen content was significantly higher in trained rats CP<0.05). Changes in plasma obestatin levels and Fundus ATP content were not significant. Data indicate that treadmill exercise was able to reduce fundus obestatin concentrations and this reduction was accompanied with a higher liver glycogen content in trained rats. Exercise training might modulate fundus obestatin levels via an improvement of energy source.