اثر تمرين هوازي بر غلظت گرلين و لپتين پلاسمايي زنان چاق و با وزن طبيعي

Effects of Aerobic Training on Plasma Ghrelin and Leptin Levels in Obese and Normal-Weight Women

Leptin and ghrelin are two hormones that have been recognized to have a major influence on energy balance.We examined the effects of aerobic training on ghrelin isoforms in obese and normal weight women. Eighteen sedentary, obese women [44.3± 5.83(yr) and BMI 30.5± l.6(kg/m2)] and eighteen normal-weight [4l.5± 6.03 (yr) and BMI 24± l.3(kg/m2)] were randomly assigned in aerobic exercise and control groups. Subjects performed 30 min running with 65-75% maximal heart rate reserve, 4 d/wk for 8 weeks. Before and after 8 weeks intervention, acylated (AG), unacylated ghrelin (UAG) and leptin (Eliza kits), insulin, body weight and Vo2max was measured for all subjects. With one-way ONOVA in the obese exercised group, UAG levels significantly increased after intervention compared to others (p<0.00l), while body mass and leptin decreased significantly (p<0.00l, p<0.02). There were no significant changes in AG levels following the intervention in either exercised groups compared to controls (p<0.20). In summary, fasting UAG and leptin oncentration respectively to be increased and decreased by aerobic exercise accompanied with loss of body weight.