تاثير يك دوره بي تمريني و تمرين مجدد بر مجموعه t-PA/PAI-1 در موش هاي صحرايي نر

The Effect of Detraining and Retraining on t-PA/ PAI-1 Complex in Male Rats

Many studies have been done on effects types training on blood hemostatic. However effects detraining and retraining on this index and especially t-PA/PAI-1 complex are unclear. The purpose of the present study was to determine the effect of four weeks detraining and retraining after 8 weeks of the continuous training on t-PA/PAI-1 complex in rats (203±15/5 gr, and old-3month). Sixty-four rats of the male wistar were involved and were divided into main experimental and control groups, and subgroups. The training protocol took part for period of 8 weeks and 5 days in week with defined speed and duration extention. The detraining protocol was performed for 4 weeks and the retraining protocol was performed for duration 4 weeks. PAI-1, t-PA and t-PA/PAI-1 complex were measured by enzyme-linked immnosorbent assay (ELISA). The results was showed significant increase t-PA and t-PA/PAI-1and insignificant decrease PAI-1 after 8 weeks training on experimental group as compare control group with similar age. Furthermore PAI-1 increased and t-PA levels and t-PA/PAI-1 complex decreased on experimental group on detraining and retraining stages and these interventional changes only at retraining stage signification on compare 8 week training. Moreover changes value t-PA/PAI-1 com-plex on experimental group at detraining and retraining significant an compare control group. Whereas exterven-tional changes t-PA and PAI-1 only significantly on following 4 weeks detraining. In Conclusion, 4 weeks detraining has unfavorite effects on blood hemostasis and moreover, 4 weeks retraining have been little effects on blood hemostasis. Therefore need training continuous.