درمان واژينوز باكتريال در بارداري و تاثير آن بر نتايج بارداري

The Effect of Treatment of Bacterial Vaginosis on Pregnancy Outcome

Introduction: Prematurity is one of the most common causes of neonatal mortality in many countries. Recent studies show that bacterial vaginosis during pregnancy can lead to some complication such as premature rupture of membrane and preterm labor. The aim of this study was evaluation of bacterial vaginosis and ils pmphjlactic effect on premature rupture of membrane and preterm labor Methods: 500 singlton pregnant women who were referred to Hafez Prenatal Clinic affiliated to Shiraz University of Medical Sciences from October 2006 till October $607 took part in a double blind clinical trial. Gram stain was prepared from their vaginal discharge and those with positive results were divided into two groups. One group received vaginal metronidazole and the Otbffr received placebo for 5 days. Reassessment by Gram stain was done two weeks alter termination of treatment and also in weeks 32 and 3"1 of pregnancy. Premature rupture of membrane and preterm labor rate were assessed in both groups. Data were analyzed by SPSS 15 and using 1 islicrʹs exact test and chi-square test. Results: Bacterial vaginosis occurred in 22.4% of pregnant women. Gram stain of vaginal smear changed lo negative in 52 women (91.2%) in treatment yroup. Premature rupture of membrane \ is less freque tong mouonida^de gros!| ip u.iHJT). * -J a- 3 a Conclusion: Vaginal metronidazole is effective in treatment of bacterial vaginosis in pregnancy and can reduce premature rupture of membrane in these patients. Screening and treatment of bacterial vaginosis in pregnancy is highly suggested