اثر ضددرد تجويز درازمدت آنتوسيانين سيانيدين در موش صحرايي ديابتي: شواهد رفتاري

Antinociceptive effect of chronic administration of the anthocyanin cyanidin in diabetic rats: Behavioral evidence

Aims: The pain caused by peripheral nerve neuropathy is one of the most frequent complaints of diabetic patients. Nowadays, researchers are looking for new extracts of therapeutic herbs as a cure for diabetic hyperalgesia due to lack of proper and safe medications. Cyanidin is a potent antioxidant and anti-inflammatory agent, which reduces oxidative stress and also plays an anti-diabetic role in type II of diabetes mellitus. This study was designed to investigate the antinociceptive effect of cyanidin in diabetic rats. Materials & Methods: 48 rats were used in this case-control study. Rats were divided into control, cyanidin treated control, diabetic, sodium salicylate treated diabetic, and cyanidin treated diabetic groups. Intra peritoneal cyanidin injection was performed one week after diabetes induction for two months. Pain threshold and nociception were evaluated using hot water tail immersion and formalin tests respectively. Data was analyzed by SigmaStat 3.5. Results: Cyanidin treated diabetic rats had lower nociceptive scores at chronic phase of formalin test. Cyanidin treatment didnʹt cause a significant change in tail immersion latency in diabetic rats. Conclusion: Although chronic treatment with cyanidin does not affect pain threshold but significantly reduces nociception in an experimental model of diabetes mellitus and this may be considered as an auxiliary treatment for diabetic hyperalgesia. Keywords: Cyanidin, Diabetes Mellitus, Pain, Formalin Test, Hot Tail Immersion Test