اندازه گيري فشار اكسيژن ادرار به عنوان روش بررسي عملكرد زودهنگام كليه در بيماران تحت جراحي قلب باز

Urine oxygen pressure measurement as an early renal function assessment in patients undergoing open heart surgery

Aims: Annually, one million people worldwide undergo coronary revascularization with use of cardio-pulmonary bypass. The metabolically active medullary thick ascending loop of Henley is particularly vulnerable to hypoxia. Change in renal bio-markers is delayed and therefore checking them is not a proper way for early assessment of acute kidney injury. In this study, measurement of Urine Oxygen Pressure (PU02) is examined for assessment of early renal function in patients undergoing open heart surgery. Materials & Methods: This cohort study was performed on 101 patients referred to one of Tehranʹs hospitals for open heart surgery. Fresh urine sample from Foley catheter (for measuring PU02) and Arterial blood sample (for measuring Pao2) was taken before cardio-pulmonary bypass and every 30 minutes after cardio-pulmonary bypass. 24 hour creatinine clearance, 24 hour urine volume, Cr and BUN levels were documented after operation. Data was recorded in separate charts and was analyzed by SPSS 11. Results: Relationship between PU02 and decrement of creatinine clearance demonstrates significant statistic difference. Relationship between Urine Flow rate and decrement of creatinine clearance demonstrates no meaningful statistic difference. Conclusion: PU02 measurement can be applied for real time assessment of early renal function in patients undergoing open heart surgery. Keywords: Cardio-Pulmonaiy Bypass, Acute Kidney injury, Urine Oxygen Pressure