تاثير پروپوفول در جلوگيري از افزايش فشار چشم بدنبال تزريق سوكسينيل كولين و لوله گذاري ناي

Preventive effect of propofol against increased intra-ocular pressure caused by succinylcholine injection and endo-tracheal intubation

Background and purpose: Penetrating eye injury is one of the most frequent trauma admitted in ophtalmological emergency rooms. The major concern when treating such a trauma is increased intra¬ocular pressure and vitreous loss as a side effect of Succinylcholine and endotracheal intubation with 110 appropriate substitute drug available yet. This study is aimed to determine whether the use of Propofol can prevent the increase intra-ocular pressure caused by succinylcholine injection and endotracheal intubation. Materials and methods: 46 cases were selected and classified on the basis of American Society of Anesthesiologistsʹ Physical Status I, II (ASAPS I, II). Before induction of anaesthesia, intra-ocular pressure was measured for each individual case using Schiotz tonometer. Then, anaesthesia was carried out using Propofol (mean: 3mg/kg) and succinylcholine (mean: 1.2mg/kg) while endo-tracheal tube being placed in the trachea. Intra-ocular pressure was measured using the same method immediately and 2 minutes after intubation. Repeated measurements test and correlation co-efficient was used to compare the mean difference and correlation between measurements. SPSS version 16 and SAS-9.1 were used to conduct all statistical analysis. Results: 33 patients, of them 13 female cases (39.4%) and 20 male (60.6%) cases have shown a mean intar-ocular pressure of 12 mmHg prior to induction. After intubation, their immediate and two minutes intar-ocular pressure were 10.69 and 9.93 mmHg respectively. Conclusion: Our study shows not only the intra-ocular pressure is not raised but also it is decreased by rapid induction of Propofol followed by injection of succinylcholine and endotracheal intubation. Key words: Succinylcholine, intra-ocular pressure, rapid sequence induction, propofol