نقش ضخامت اندومتر در موفقيت روش درمان ناباروري

The role of the endometrial thickness in success of infertility treatment using Zygote Intra-Fallopian Transfer method (ZIFT)

Background: Many studies have evaluated the effect of endometrial thickness on pregnancy rates (PRs) in Assisted Reproductive Technology (ART) patients. The results obtained were controversial. The aim of this study is to evaluate this effect in the ZIFT technology output. Methods: In this case-control study a total of 90 females who have been referred to the infertility center and treated using ZIFT with the long protocol, were entered into two groups: sucessfully fertalized and unsuccessfully fertalized women regarding to the treatment results, and evaluated retrospectively for their demographics and increase in their endometrial thickness in response to the treatment. Results: The endometrial thickness in response to the gonadotropin stimulation From the 7th to 12th day was greater than 2 mm in the successful group, whereas this increase was lesser than 0.3 th mm in unsuccessful group, althogh, there was no statistically significant difference between two groups in the case of this messures (P=0.178). Moreover, the endometrial thickness in 7th and 12th days of the Human Chorionic Gonadotropin(HCG) infusion, werenʹt significantly different between two groups (P=0.372 for 7th day, P=0.096 for 12th day). Conclusion: Our study declines the role of the endometrial thickness response to the gonadotropin stimulation in the prognosis of the ZIFT for a successful pregnancy. On the other hand, the thickness of the endometrium in the 7th day of Gonadotropin infusion and threshold value of 8 mm in the 12th day that has been emphasized in some references lacked their prominence in our study