پديد آورندگان :
hosseini، m نويسنده islamic azad university, north tehran branch,faculty of chemistry , , alipour، e. نويسنده islamic azad university, north tehran branch,faculty of chemistry , , alipour، e. نويسنده researching and development center,fanda Pharmaceutical company , , kebriaee zadeh، a. نويسنده tehran university of medical science,faculty of pharmacy and Pharmaceutical sciences research center , , hosseini، m نويسنده researching and development center,fanda Pharmaceutical company , , samadian، a.a. نويسنده researching and development center,fanda Pharmaceutical company , , kebriaee zadeh، a. نويسنده researching and development center,fanda Pharmaceutical company ,
چكيده فارسي :
Vlenlafaxine (V EN) belongs to a group of Antidepressant with a novel chemicalV structure which has a structure that dose not resemble those of any currently usedant idepressants. A rapid, specific reversed-phase HPLC method has been developedfor assaying VEN in pharmaceutical dosage forms. The cxprimcnt involved an isdone by CI8column using a mobile phase composition of water (pH:3.6±0,05, 25 mMpotassium dihydrogen phosphate) and Acetonitril (60:40, v/v ), The flow rate was ImLimin and analyte monitored at 225 nm. The assay method was found to be linearfrom 5 to 16 ug / ml. All the validation parameters were within the acceptance range.The developed method was successfully applied to estimate the amount of VEN IIItablets
