بررسى اثرات ضد ميكروبي عسل بر روي آلودگى رودها ى با باكترى سالمونلاتيفي موريوم ( PTCC,1547 ) در موش هاي سورى نر

Antimicrobic affects of honey on intestinal infections with Salmonella typhimurium bacteria PTCC, 1547 in male mice

Regarding the importance of digestive system disease with salmonella origin, different methods for prevention and therapy seems to be necessary and considering the several side-effects of drugs and also drug resistance especially toward synthetic medicines had led researchers to concentrate on drugs with natural origin. Honey is used as a curing material in various bacterial infections. In this research, antimicrobic effects of honey and comparison of its using frequency on mice infected with Salmonella typhimurium was studied. In this study, different experimental investigations on 4 groups of lab mice including a group with simultaneous treatment of honey and bacteria injection (group 1); a group with bacteria injection and then treatment with honey after infection (group 2); a group with bacteria injection without any treatment (group 3) and finally a control group have been performed. The infecting operation was performed through injection of 1 ml of Salmonella typhimurium bacteria in neck area and honey treatment with dilution of 6:1. Comparison of average bacteria numbers in excretion samples of 4 experimental groups showed that there is a meaningful relation (P=0.01) between control and three other groups. The average of bacteria in 1st group (6.12+3.56) compared to 2nd (18.87+5.57) and 3rd (127.50+33.75) groups revealed a significant reduction. Reciprocal effects of sampling dates in experimental groups showed a considerable difference (P=0.01) between honey treatments in reduction of intestinal infection severity with Salmonella origin. Results of this study maintain that using honey in daily diet will lead to reduction of intestinal disease.