آناليز پيوستگي جايگاه هاي ژني dfnb12، dfnb40 ،dfnb9 در مبتلايان به ناشنوايي غير سندروميك

Genetic Analysis of DFNB9, DFNB40 and DFNB12 in Patients with Autosomal Recessive Non Syndromic Hearing loss

Autosomal recessive non syndromic hearing loss (ARNSHL) is the most common form of hearing impairment and is extremely heterogenous. Mutation in the genes that encode connexin 26 and 30 is the main reason of sever which causes deafness (up to 50% of cases). In this study we screened 50 Iranian families with ARNSHL which were negative or heterozygote for GJB2 mutations. The homozygosity mapping of these families was performed using STR polymorphic markers. The results showed that mutation in OTOF gene (DFNB9), CDH23 gene (DFNB12) and DFNB40 locus are not the main reasons of non syndromic hereditary hearing loss in our population and other loci should contribute to ARNSHL in Iranian population.