گزارش يك مورد لنفوم سلول مانتل با پوليپوز متعدد لنفوماتوز

case of Mantle CellLymphoma with Multiple Lymphomatous Polyposis

Multiple Lymphomatous Polyposis (MLP) is characterized by multiple polyps involving long segments of the GI tract. More than 75% of the cases are derived from pregerminal center B cells (mantle zone B cells) & less than 25% from germinal center B cells. Thus MLP is a heterogenous group that includes Mantle Cell Lymphoma (MCL) & Follicular Lymphoma (FL). Here we present a 75-year-old sailor who referred to us with abdominal pain, bloody diarrhea, iron deficiency anemia & lymphadenopathy in inguinal & femoral regions. The presence of intestinal polyposis in colonoscopic & endoscopic evaluations & the pathologic & immunohistochemical findings on tissue specimens that showed B cell lymphoma with moderate proliferative activity (50%) & nodular proliferation of small lymphocytes; accompanied with positivity for CD5, CD20, CD43 & negativity for CD3, CD 10, CD23 revealed that these findings are consequent to MCL with accompanied MLP. Keywords: mantle cell lymphoma, multiple lymphomatous polyposis, none hodgkinʹs lymphoma, polyposis *Address for correspondence: Department of gastroenterology, School of Medicine, Bushehr University of Medical Sciences; E-mail: mohamadsalehtabib@yahoo.com