بررسى اثر تزريق سلول هاى بنيادى مغز استخوان به بطن طرفى مغز پس از ايجاد ضايعه طناب نخاعى در رت

The effects of cell administration on Alpha motoneurons regeneration after spinal cord injury (SCI) in Rat

There are many evidences that degeneration process after spinal cord injury danbe a good reason for nervous system (peripheral and/or central) problems. In this research the effects of cell administration on alpha motoneurons regeneration after spinal cord injury (SCI) in Rat was investigated. Twenty four male wistar rats divided to 3 groups (control. (SCI). (SCI) + stem cell administration n=8).After 4 weeks the lumber segments of spinal cord were sampled. processed. sectioned serially and stained with tolu-idine blue (PH=4.65).By using sterological quantitative technique (physical dissector). the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared with each other. Statistical analyses showed that the treatment with stem cell significantly (P<0.05) reduced neuronal damage after weeks and improve the regeneration. The numerical density in this group was near to control group. It was consulted that cell administration could reduce the degeneration rate of alpha motoneurons after spinal cord injury (SCI) in Rat.