مقايسه دو روش تشخيصي غلظت سرمي سيستاتين- سي و كراتينين به عنوان تست هاي تشخيص دهنده آسيب حاد كليوي بعد از تروماي شديد طي 24 ساعت اول بستري در بخش هاي مراقبت هاي ويژه بزرگسالان

C omparison of two diag¬nostic methods of cysta- tin-c and serum crea¬tinine level for the diagnosis of acute kidney injury after sever trauma within the firsth 24 hours in adult intensive care units

Background: Acute kidney injury (AKI) is a common clinical problem in critically ill patients such as post traumatic situations. One of the main causes of poor outcome in these patients is lack of valuable serum markers for early diagnosis of AKI. In this study we compared cystatin-C and creatinine for estimation of GFR as a markers of AKI. Materials and methods: we prospec¬tively evaluated 300 patients admitted in adult intensive care units of a referral university affiliated hospital. Serum cystatin -C and serum creatinine were used to assess renal function according to RIFLE eriteria to diagnose AKI. Results: The crude Incidence of AKI according to RIFLE criteria based on GFR calculated with Creatinine was 14.7% and based on GFR with cystatin-C was 7%. Creatinine level was increased better than cystatin-C in the first 24 hours. Discussion: AKI can be diagnosed by Creatinine level better than cystatin-C in the first 24 hours, so it is a better markers for evaluation of AKI.