بررسي تاثير سايمتيدين وريدي در كاهش ميزان بروز و شدت درد حين تزريق ديازپام و مقايسه آن با ليدوكائين؛ كارآزمايي باليني تصادفي شده دوسوكور با كنترل دارونما

T he efficacy of IV cimetidine decreasing pain prevalence and intensity during diazepam injection and comparison with lidocaine; a randomized double blind placebo controlled clinical trial

Background: ft has been shown that antihistamines prolong the duration of antinociceptives. The aim of this study was to compare the efficacy of cimetidine and lidocaine in decreasing pain prevalence and intensity during diazepam injection as anesthesia premedication. Materials and methods: In a randomized, double-blinded, placebo - controlled prospective study, 60 ASA I & II patients scheduled for elective surgery under general anesthesia in Imam Khomeini Hospital in 1382 were enrolled. Patients with history of drug abuse or narcotic drug consumption or psychological disorders were excluded from the study. They were randomly assigned into three groups, case group (received 2ml of normal saline), lidocaine group (received 40 mg lidocaine) and cimetidine group (received 200 mg cimetidine) intravenously prior to diazepam injection. Pain intensity was measured using VAS system and patients were followed the day after surgery for thrombophelebitis. Results: The age mean was 32.7±9.5. There was no significant difference in mean of age, weight, gender and ASA status between groups (p>0.05). The pain mean during diazepam injection in lidocaine and cimetidine groups were significantly lower than ease group (1.50 and 1.90 vs. 5.30 respectively, p<0.05) but there was no significant difference between lidocaine and cimetidine groups (p>0.05). Also there was no significant difference in thrombophelebitis occurrence between groups (20% & 5% vs. 15% respectively, p>0.05). Conclusions: Intravenous administration of cimetidinc before diazepam IV injection, results decreasing in pain on injection of diazepam.