اختلالات اسيد و باز و عوامل موثر بر آن در روش بيهوشي كامل داخل وريدي

Acid-base disturbances and its related factors in patients under total intravenous anesthesia

Abstract Aims: Anesthesia duration is a risk factor of mortality and complications related to anesthesia. Metabolic acidosis is formed in patients who undergo inhalational anesthesia and has shown correlation with anesthesia duration. This study was performed in order to assess the acid-base disturbance prevalence and its related factors in total intravenous anesthesia. Materials & Methods: This descriptive study was performed on 69 patients selected by random sampling method, who referred to one of Tehranʹs hospitals for elective surgery in year 2009. They were studied in 3 groups of Head and Neck surgery, extremities and abdominal surgery group. Continuous Propofol and Remifentanil infusion was used for anesthesia and acid-base status was measured. Data was analyzed using Chi square, variance analysis, repeated measurements and dependent t-test by SPSS 11.5 software. Results: Metabolic acidosis was significantly correlated with anesthesia duration. The prevalence of acidosis in Head and Neck group was greater than the two other groups. There was no significant relationship between acidosis and core body temperature changes and type and volume of injected intravenous fluids. There was no significant relationship between acidosis requiring treatment and site of surgery and anesthesia duration. Conclusion: Metabolic acidosis prevalence requiring treatment in total intravenous anesthesia is 3% and using total intravenous anesthesia including Propofol and Remifentanil in long duration anesthesia is recommended in order to reduce metabolic acidosis related complications. Keywords: Acid-Base Disturbances, Total Intravenous Anesthesia, Surgery