مقايسه تأثير ريباكسين و دارنما در درمان بالغين مبتلا به اختلال بيش فعالي كم توجهي در يك مطالعه باليني دو سوكور

Comparing Therapeutic Effects of Reboxetine with Placebo in Adult Patients with Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled Clinical Trial

Background and Objective: Attention-deficit-hyperactivity disorder (ADHD) in adults is accompanied with different complications such as decreased occupational and educational performance. At present, stimulant drugs are used as the first line treatment in this disorder. However, possible development of side effects and dependence on these drugs are of concern. Therefore, it was decided to evaluate the efficacy of reboxetine in the treatment of adults with attention-deficit-hyperactivity disorder. Subjects and Methods: Forty adult diagnosed with ADHD without any significant psychiatric disorder were participated in a 6-weeks a double blind clinical trial with reboxetine (8 mg/d) in two divided doses. The principle measured outcome was the Connerʹs ADHD Rating Scale (adult version). Results: Rate of response (decrease of Connerʹs rating scale scores) in reboxetine group were significantly greater than control group (p<0/001). Conclusion: Reboxetine may be an effective treatment for the adult with attention-deficit/ hyperactivity disorder. Sci Med J 2010; 9(5):483-493