پديد آورندگان :
Changizi-Ashtiyani، Saeed نويسنده Department of Physiology, Arak University of Medical Sciences, Arak, Iran Changizi-Ashtiyani, Saeed , Zarei، Ali نويسنده Department of Animal Biology, Unit of Science Research, Islamic Azad University of Damghan, Damghan, Iran Zarei, Ali , Taheri، Soheila نويسنده Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran , , Rasekh، Fateme نويسنده Department of Plant Biology, Payam-e-Noor University, Tehran, Iran Rasekh, Fateme , Ramazani، Majid نويسنده Department of Internal Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran Ramazani, Majid
كليدواژه :
Atorvastatin , Cholesterol , Hypercholesteroleomia , Rat , Portulaca oleracea , Triglyceride
چكيده لاتين :
Background: Hypercholesterolemia is a major risk factor for cardiovascular diseases. Portulaca oleracea is a vegetable, known in traditional medicine and has many medicinal properties. In the present study the effects of alcoholic extract of Portulaca oleracea on blood fat profiles are evaluated.
Materials and Methods: In this experimental study, 60 Wistar rats in the weight range of 170±5 g in 6 groups (n=10) were selected as follows: Control group receiving normal diet, Sham group receiving high fat diet, experimental groups receiving the Portulaca oleracea extract with maximum dose(800 mg/kg), moderate dose (400 mg/kg) and minimum dose (200 mg/kg) as intraperitoneally and injection of 10 mg/kg atorvastatin and treated with high fat diet for 21 days. After the end of this period, blood sampling and measuring obtained samples, data was analyzed using SPSS-11.5 software
Results: Based on the results obtained from all groups receiving the extract of Portulaca oleracea herb, it was found that the level of cholesterol concentration in these groups and the level of cholesterol and triglyceride concentrations in the group receiving atorvastatin significantly decreased (p? 0.05), but the plasma concentration of high and low-density lipoproteins did not show any significant changes.
Conclusion: The results of this study show that oral intake of alcoholic extract of portulaca oleracea can play an important role in reducing cholesterol levels, similar to the use of atorvastatin. This performance is probably more related to the high density of antioxidants and omega-3 found in this herb and mechanisms of the cholesterol synthesis inhibition.
