بررسي تاثير روزه داري بر قندخون ناشتا، پروفايل ليپيدي وآنزيم هاي كبدي

Effect of Fasting on Fasting Blood Glucose, Lipid Profile and Liver Enzymes

چكيده مقدمه: در ماه مبارك رمضان بيش از 400 ميليون مسلمان به روزه داري مي پردازند با توجه به شيوع بالاي ديابت و اختلالات ليپيد و اختلال در سطح آنزيم هاي كبدي و نيز تناقض هاي موجود در مورد تاثير روزه بر شاخص هاي متابوليك و ابعاد ناشناخته روزه داري بر آن شديم تا اثرات روزه داري را بر اندكس هاي فوق( قندخون ناشتا، تري گليسريد، كلسترول تام، LDL، HDL و آنزيم هاي كبدي) را بررسي نماييم. مواد و روش ها: روش پژوهش حاضر مطالعه مقطعي كه بر روي 120 نفر از مراجعان بيمارستان مصطفي شهرستان ايلام در سال 91 صورت گرفته است تمام افراد با رضايت كامل و با رعايت اصول اخلاقي وارد طرح شدند. افرادي كه در طول مطالعه روزه دار نبودند خارج و حجم نمونه به 98 رسيد. قبل از شروع ماه رمضان و آخرين روز ماه رمضان اندكس هاي( قندخون ناشتا، تري گليسريد، كلسترول تام ، LDL، HDL و آنزيم هاي كبدي) اندازه گيري شدند آنزيم هاي كبدي به وسيله دستگاه BT3000 اندازه گيري شد و براي آناليز داده ها از آزمون T-TEST زوجي استفاده گرديد يافته هاي پژوهش: ميانگين و انحراف معيار آنزيم ALT قبل از ماه رمضان U/mL 44/17±15/23 و بعد ماه رمضان U/mL 85/34±32/29 كه از نظر آماري معنا دار مي باشد.(P=0.02) ميانگين و انحراف معيارLDL قبل از ماه رمضان mg/dL 84/25±106 بعد از ماه رمضان mg/dL 12/22±99/94 كه از نظر آماري معنادار مي باشد.(P=0.000) ميانگين و انحراف معيار گلوكز mg/dL 25/12±54/85 و بعد از ماه رمضان mg/dL 97/13± 17/ 85 مي باشد.(P=0.7) بحث و نتيجه گيري: در اين مطالعه ميانگين تري گليسريد،LDL كاهش پيدا كرده اما افزايش معناداري در ALTو HDL بعد از روزه داري ايجاد شد. تفاوت معني داري بين نوبت اول و دوم گلوكز پيدا نشد. و سطح كلسترول توتال بعد از رمضان افزايش معناداري داشت

Abstract Introduction: More than 400 million of Muslims deal with fasting during the fasting month of Ramadan. Given the high prevalence of diabetes, lipid disorders, and abnormalities in liver enzyme levels and also the presence of contradictions about the effect of Ramadan fasting on metabolic parameters, we decided to assess the effect of Ramadan fasting on the above metabolic indices. Materials & Methods: The before and after study was carried out on 120 subjects referred to the Mustafa hospital in Ilam city during 2012. All subjects were included into research according to ethical standards and after signing a written informed consent. People who were not fasting during Ramadan excluded from the study and the sample size was designed to be 98 subjects. Before and the days of Ramadan, the metabolic indices (fasting blood glucose, triglycerides, total cholesterol, LDL, HDL and liver enzymes) were measured. The indices were measured by BT3000 instrument and the paired t-test was used to analyze data. Finding: The mean levels of alanine transaminase (ALT) enzyme were 17.44±23.15 U/mL before Ramadan and 34.85±29.32 U/mL after Ramadan, which their difference was statistically significant (P=0.02). The mean levels of LDL were 25.84±106 mg/dL before Ramadan and 22.12±94.99 mg/dL after Ramadan, which their difference was statistically significant (P=0.000). The mean levels of glucose were 85.54±12.25 mg/dL before Ramadan and 85.17±13.97 mg/dL after Ramadan, which their difference was not statistically significant (P=0.07). Discussion & Conclusion: In the study, the mean levels of triglyceride, LDL and HDL reduced but significant increase in ALT was created after fasting. No significant difference was found between the glucose levels before and after Ramadan. And total cholesterol levels were significantly increased after Ramadan.