تاثير شش ماه تمرين هوازي بر سطوح هورمون رشد، IGF-1 و نسبت GH به IGF-1 سرمي زنان ميانسال غيرفعال

The Effect of a Six- Month Aerobic Exercise on Levels of GH, IGF-1 and GH/IGF-1 Ratio Serum in Sedentary Middle-aged Women

مقدمه: در سال هاي اخير تحقيقاتي در مورد رابطه آترواسكلروز و سطح سرمي GHو IGF-1 انجام شده و نتايج متفاوتي به دست آمده است. هدف از اجراي اين پژوهش بررسي اثر شش ماه تمرين هوازي بر غلظت هورمون رشد، IGF-1 و نسبت GH به IGF-1 سرمي زنان ميانسال غيرفعال بود. روش بررسي: در اين تحقيق 19 آزمودني در دو گروه تجربي (11 نفر) و كنترل (8 نفر) به روش نمونه گيري در دسترس و هدفمند انتخاب شدند. آزمودني ها به مدت 6 ماه و هر هفته 3 جلسه و هر جلسه60 دقيقه در تمرينات هوازي با شدت 55 تا 65 درصد ضربان قلب ذخيره حضور يافتند. پيش از شروع و پس از پايان دوره 6 ماه تمرين هوازي، نمونه خوني جمع آوري و GH و IGF-1 سرمي اندازه گيري شد. براي مقايسه ميانگين هاي درون گروهي، بين گروهي و بررسي اثر تعاملي از روش آناليز واريانس اندازه هاي تكراري و نرم افزار SPSS نسخه 15 استفاده شد. نتايج: سطح IGF-1 سرمي زنان ميانسال طي شش ماه تمرين هوازي كاهش معني داري يافت (016/0=p). همچنين، سطح GH سرمي در طي اين دوره تغيير معني داري نداشت. نسبت GH/IGF-1 داراي افزايش معني داري بود (007/0=p). نتيجه گيري: نتايج حاكي از آن است كه تمرين هوازي سطح فاكتور شبه انسوليني نوع 1 كه با شدت ضايعه عروق كرونر ارتباط معني دار دارد را كاهش مي دهد و شايد بتوان با انجام تمرين هوازي از بروز بيماري آترواسكلروزيس جلوگيري نمود.

Introduction: In recent years, a number of researches have been carried out regarding the relationship between atherosclerosis and serum levels of GH and IGF-1 and different results were obtained. This study aimed to determine the effect of a six-month aerobic exercise on levels of GH, IGF-1 and GH/IGF-1 ratio serum in sedentary middle-aged women Methods: Nineteen healthy females, who were selected by convenience sampling method, were divided into two [active (n=11) and non-active (n=8)] groups. The exercise protocol included aerobic exercise training lasted for 6 months and 3 sessions per week. Every session lasted for 60 minutes with intensity of 55-65 percent of heart rate reserve. Blood samples were taken and Serum IGF-1 and GH were measured before and after six months of aerobic training. To make intra and intergroup comparisons as well as to investigate the interactive effect, repeated measure analysis of variance were used. For all statistical comparisons, the level of significance was set at p < 0.05. Results: This study demonstrated that the level of serum IGF-1 in middle-aged women decreased significantly (P=0.016). However, the levels of GH didnʹt change significantly during this period. Moreover, GH to IGF-1 ratio increased significantly (P=0.007). Conclusion: The study results indicated that six-month aerobic exercise led to a decrease on the levels of IGF-1 and did not make a change in GH serum in sedentary middle-aged women. In other words, doing aerobic exercises reduced IGF-1 levels that have a significant relationship with severity of a coronary disease and thus can prevent the atherosclerosis disease.