كليدواژه :
Morphine , فارماكولوژي , Behavioral Sensitization and Tolerance , حساسيت , mouse , مورفين , Papaver , تحمل رفتاري , شقايق , موش آزمايشگاهي نر
چكيده لاتين :
Opioid addiction is one of the main problems for the health services. In the present study, the effects of water-alcohol extract of Papaver rhoeas on the expression and acquisition of morphine-induced behavioral sensitization were investigated.
Mice became sensitized (5 mg/kg, once daily, for three consecutive days; s.c.) or tolerate (50 mg/kg, twice daily for three consecutive days; s.c.) to morphine and the extract before the morphine injection (acquisition) or on the test day (expression) was administrated to them. In a pilot study, different doses of morphine and the extract were administered to the animals in order to evaluate if the drugs can produce any locomotion effects.
Results showed that: subcutaneous (s.c.) administration of morphine (0.5-50 mg/kg) increased locomotor activity in the animals. The response was more significant in dose 50 mg/kg of morphine. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Daily injection of morphine (5 mg/kg; s.c.) for three consecutive days and then five days resting induced sensitization in the animals, so that the morphine sensitized animals showed an extra ordinary response to the ineffective dose of morphine (5 mg/kg; s.c.). Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine-induced behavioral sensitization. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test, also decreased the expression of morphineinduced behavioral sensitization. Injection of morphine (50 mg/kg; twice daily) for three consceutivc days, induced tolerance in the animals, so that the morphine tolerated animals did not ;w any response to the effective dose of morphine (50 mg/kg; s.c.). Injection of extract (25, 50 and 100 mg/kg, i.p) 3omin before the morphine administration decreased the acquisition of morphine-induced Tolerance, Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test, increased the expression morphine-induced behavioral tolerance.
It could be concluded that the extract of Papaver rhoeas can reduced both the acquisition and expression of morphine-induced behavioral sensitization and also the acquisition of. morphine tolerance but enhances the expression of morphine tolerance in mice which may be true in the human.
