پديد آورندگان :
قاروني، فاطمه نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Gharoony, Fatemeh , عريان، شهربانو نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Oryan, Shahrbanoo , نبيوني، محمد نويسنده دانشكده علوم زيستي,گروه علوم سلولي ومولكولي,دانشگاه خوارزمي,تهران,ايران Nabiuni, Mohammad , اسليمي اصفهاني، دلارام نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Eslimi Esfahani, Delaram , حسيني نيا، طليعه نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Hosseinynia, Talieh , كريميان پيرو، منيژه نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Karimian Peiro, Manijeh , پارسا، سودابه نويسنده دانشكدۀ علوم زيستي,گروه علوم جانوري,دانشگاه خوارزمي,تهران,ايران Parsa, Soudabeh
كليدواژه :
كلسترول , اندوتوكسين , نكروز , bile acids , Bilirubin , Cholesterol , necrosis , بيلي روبين , اسيدهاي صفراوي , Endotoxin
چكيده لاتين :
Cholestasis caused by the excessive accumulation of bile within the liver, due to intrinsic or extrinsic factors. Cholestasis side effects are associated directly or indirectly with the reduction of bile flow and the confinement of materials related to bile secretion (such as bile acids, bilirubin, and cholesterol). On the other hand, some factors such as opioids, alkaline phosphatase, endotoxin and nitric oxide increase in blood, which could cause tissue damage. Since water intake reduces during cholestasis andhypothalamic nuclei such asparaventricular andsupraoptic nucleuses are involved in the regulation of body water Therefore, in this study, the histopathological changes of hypothalamic nuclei were evaluated. Male Wistar rats weighing 200–250 g were randomly divided into three groups. Three sets of seven groups were unoperated control, sham operated and bile duct ligated rats. The tissue sles were analyzed using histotechnique and light microscope. Brain tissue necrosis in paraventricular and supraoptic nucleus in cholestatic rats increased, but in the sham and control rats no changes were observed and also cholestasis caused wrinkle chromatic nuclei and increased thickness of hypothalamic nuclei.Because endotoxin causes tissue trauma, it is likely increased endotoxin may leads to tissue changes in the brain.