اثر اسانس گياه آنيسون بر كسب و پايداري ترجيح مكان شرطي شده ناشي از مورفين در موش سوري نر

Effects of the Anisun Pimpinella Essence on Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Mice

The problem of drug dependence still remains unsolved. In the present study the effects of the essence of anisum pimpinella on the expression and acquisition of conditioned place preference (CPP) induced by morphine in mice were investigated. Male albino Swiss-Webster mice (20-25gr) were used. The Carr and White method was applied for the induction of CPP. Intrapretoneal (IP) injection of morphine (5mg/kg) induced CPP significantly. However, injection of essence (0.125-0.5 m1/kg; IP) induced conditioned place aversion (CPA). Although administration of essence before the test had no effect on morphine action. Co-administration of the essence (0.25m1/kg) with morphine in the training days reduced the morphine effect. Pre-treatment of animals with bicuculline a GABAA receptor antagonist (1.5mg/kg) diminished the effect of the essence on morphine induced CPP but this result was not found for CGP35348 (GABAB receptor antagonist). These results show that the essence of the anisum pimpinella may reduce morphine effects via a GABAergic mechanism.