در استان خراسان HTLV-1 آلوده به ويروس T ايجاد رده سلولي لنفوسيت

Establishment of HTLV-I Infected T-Cell Line in Khorasan Province

HTLV-I is a virus of to the retroviruse family with endemic areas in the world. One of in the Khorasan province with 2.3% prevalence in the general population. This virus is believed to be responsible for two important diseases: ATL (Adult T-Cell Lymphoma and Leukemia) and HAM/TSP (HTLV-I Associated Myelopathy),these have a high prevalence in endemic areas of the virus. The role of this virus in causing disease and also information about if will be useful for other retroviruses like HIV. To study different aspects of the virus and related diseases we need a continca?? availability to the virus through a cell line. In this study, for the first time, we succeeded to establish a T-Cell line infected with HTLV-I from a patient with ATL disease by using PHA and discontinuous antigen non-specific stimulation in Iran. We confirmed the infectivity of the T-Cell line by IFA and PCR methods. Similar T-Cell lines had been established by researchers in other endemic countries, e.g., Japan and North America.